Journal of Clinical Investigation

HIV cell
May 21, 2015

‘Redesigned’ antibodies may control HIV: study

With the help of a computer program called “Rosetta,” researchers at Vanderbilt University have “redesigned” an antibody that has increased potency and can neutralize more strains of the AIDS-causing human immunodeficiency virus (HIV) than can any known natural antibody.

By Bill Snyder
April 30, 2015

Team tracks how kidney responds to blood pressure meds

Changes in the kidney can limit the blood pressure-lowering effects of thiazide diuretics, a new study reports.

By Leigh MacMillan
April 2, 2015

Gene variant, environment can boost RSV severity

A particular genetic mutation combined with an urban environment increases the risk of severe disease in children infected with respiratory syncytial virus (RSV), an international team of investigators has found.

By Leigh MacMillan
February 12, 2015

VU study explores inflammation, hypertension link

The evidence is increasing: the immune system and inflammation are key contributors to high blood pressure.

By Bill Snyder
Deciphering DNA code
November 20, 2014

Gene mutation linked to breast cancer therapy resistance

A group of Vanderbilt-led investigators has identified a new gene mutation that may explain why some breast cancer patients do not respond to anti-hormone therapy.

By VUMC News and Communications
baby in crib
July 24, 2014

Team spots trigger for rare diarrheal disease in infants

Researchers at Vanderbilt University, the University of Arizona and Phoenix Children’s Hospital have discovered what triggers a rare but devastating diarrheal disease in newborns that is fatal without intravenous feeding or intestinal transplant.

By Bill Snyder
July 17, 2014

Study examines therapeutic bacteria’s ability to prevent obesity

Engineered bacteria that produce a therapeutic compound in the gut prevent obesity in mice, Vanderbilt University investigators have discovered.
By Leigh MacMillan
July 10, 2014

Molecular ‘chat’ holds kidney fibrosis clues

A novel molecular “conversation” regulates kidney fibrosis – the final result of end-stage chronic kidney disease – suggesting new treatment options for this currently irreversible process.
By Leigh MacMillan
April 10, 2014

Study tracks new lung cancer drug target

Researchers at Vanderbilt University have identified a potential new drug target in subtypes of lung cancer that are difficult to treat.
By Bill Snyder
April 3, 2014

Protein’s role in spread of colon cancer studied

One of the most formidable weapons in a cancer’s arsenal is the ability to spread to other organs.
By VUMC News and Communications
March 19, 2014

Small molecule protects kidney filter

A compound identified at Vanderbilt has therapeutic potential in protecting the kidney filter barrier.
By Bill Snyder
February 20, 2014

Studies shed new light on breast cancer development

Rebecca Cook, Ph.D., assistant professor of Cancer Biology, has spent her life trying to understand what makes things grow, from seedlings in soil to tumor cells in the body.
By VUMC News and Communications
September 17, 2013

Researchers identify novel biomarker for diabetes risk

Researchers at the Vanderbilt Heart and Vascular Institute and Massachusetts General Hospital have identified a biomarker that can predict diabetes risk up to 10 years before onset of the disease.
By Kathy Whitney
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