Skip to main content

YAP after acute kidney injury

Aug. 16, 2018, 3:30 PM

by Sanjay Mishra

Acute kidney injury (AKI) — sudden and rapid failure of the kidneys — affects up to 20 percent of hospitalized patients, and up to 70 percent of ICU patients.

Studies have indicated that dedifferentiation and proliferation of surviving kidney cells contributes to kidney regeneration and recovery from AKI. EGF receptor (EGFR) and Hippo signaling pathways, which regulate cell proliferation and death, are important to this process.

Now, Jianchun Chen, MD, Raymond Harris, MD, and colleagues report in the Journal of the American Society of Nephrology that YAP, a key effector of the Hippo signaling pathway, is involved in AKI recovery.

They showed that in both human patient and mouse kidneys, YAP was activated in renal proximal tubule epithelial cells after AKI. YAP activation through an EGFR-dependent signaling pathway promotes kidney repair in response to AKI. The study suggests that YAP activation may be a target for treatment of AKI.

This research was supported by grants from the American Diabetes Association, the National Institutes of Health (DK051265, DK062794, DK079341, DK114809), and the Department of Veterans Affairs.

Recent Stories from VUMC News and Communications Publications

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer.  Don’t hesitate. Do it.

Momentum

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer. Don’t hesitate. Do it.

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

more