Vanderbilt researchers have discovered that aneuploidy (an abnormal number of chromosomes) drives malignant phenotypes in cells expressing mutant p53, a tumor suppressor protein that is mutated in more than half of all human cancers.

"The last year has been so traumatizing and hard, but to use the skills and knowledge that we have been developing to good effect in the service of others during this difficult season has been meaningful.”

A monoclonal antibody cocktail against the COVID-19 virus discovered at Vanderbilt University Medical Center and developed by AstraZeneca reduced the risk of symptoms in a study of immunocompromised and chronically ill adults later exposed to the virus by 77%, the company announced today.

Vanderbilt researchers have discovered a potential way to reduce atherosclerosis: blocking the modification of an HDL-associated enzyme by reactive molecules called isolevuglandins.

A multi-institutional team led by researchers at Vanderbilt University Medical Center has isolated monoclonal antibodies that in laboratory and animal studies prevented infection by alphaviruses, including the often-lethal Eastern equine encephalitis virus (EEEV).

Vanderbilt University Medical Center (VUMC) has received a two-year, $1.2 million award from the Tennessee Department of Health and Centers for Medicare and Medicaid Services to provide tailored education and coaching to 75 Middle Tennessee nursing homes focused on infection control, quality improvement and other pandemic-related challenges.