Leigh MacMillan

June 18, 2020

Probing DNA damage repair

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works.

June 12, 2020

Robotic technology speeds arrhythmia gene classification

Vanderbilt University Medical Center investigators have used high-throughput robotic technology to rapidly study and classify variations in a gene linked to heart rhythm disorders and cardiac conditions.

June 10, 2020

C. diff captures blood cell cofactor to build defensive shield

Vanderbilt University Medical Center scientists have identified a C. diff protein system that senses and captures heme (part of hemoglobin) to build a protective shield that fends off threats from our immune system and antibiotics.

June 9, 2020

Staph’s activation of blood clotting

Staph bacteria may change the factor they use to activate blood clotting — to evade the immune response — a new study suggests.

June 4, 2020

Protecting the injured kidney

Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it.

Jim Cassat, MD, PhD, and colleagues are studying enzymes involved in metabolism that are particularly important for Staphylococcus aureus to survive in host tissues.
June 3, 2020

Study explores how staph bacteria can survive in bone

A comprehensive evaluation of the metabolic pathways that support Staphylococcus aureus (“staph”) growth during invasive bone infections could offer new targets for treatment.