Leigh MacMillan Archive — Page 30 of 82

June 10, 2020

C. diff captures blood cell cofactor to build defensive shield

Vanderbilt University Medical Center scientists have identified a C. diff protein system that senses and captures heme (part of hemoglobin) to build a protective shield that fends off threats from our immune system and antibiotics.

June 9, 2020

Staph’s activation of blood clotting

Staph bacteria may change the factor they use to activate blood clotting — to evade the immune response — a new study suggests.

June 4, 2020

Protecting the injured kidney

Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it.

Jim Cassat, MD, PhD, and colleagues are studying enzymes involved in metabolism that are particularly important for Staphylococcus aureus to survive in host tissues.
June 3, 2020

Study explores how staph bacteria can survive in bone

A comprehensive evaluation of the metabolic pathways that support Staphylococcus aureus (“staph”) growth during invasive bone infections could offer new targets for treatment.

This is a 3D volume rendering of an MRI of a post-mortem heart obtained from a patient with COVID-19, acquired at ultra-high 500 micron spatial resolution.
May 21, 2020

Team uses imaging to study ways the heart is affected by coronavirus

Researchers are using imaging and diagnostic pathology to examine postmortem hearts donated by victims of COVID-19 to gain a better understanding of how the coronavirus that causes COVID-19 affects the heart.

May 19, 2020

Probing innate immunity

Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA.