Changes to the bone matrix that occur during aging may point to novel targets for treating osteoporosis.

D. Borden Lacy and colleagues used cryo-electron microscopy to define the structure of a C. diff toxin, providing a framework for the design of novel therapeutics.

He hopes the software applications and systems he and his team develop work so well that users don’t even notice them.

A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy.

To study the dynamics of structural proteins in the heart, Vanderbilt investigators generated a cellular tool they expect will be useful for screening drugs that affect heart muscle contraction.

Vanderbilt neurologists have identified a protein modification that could be targeted to reduce neuronal excitability in epilepsy.