Leigh MacMillan

February 6, 2013

Linking oxygen, iron and red blood cells

The HIF oxygen-sensing pathway and its responses to low oxygen may be targeted for treatments of anemia and disorders of iron balance.

By Leigh MacMillan
February 4, 2013

Brain tumor TIP reveals new target

The protein TIP-1 appears to be a novel prognostic marker for glioblastoma and may be a good therapeutic target for disrupting tumor-driven blood vessel development.

By Leigh MacMillan
February 1, 2013

Cell source of heart’s blood vessels

An unexpected group of cells generates the coronary arteries and may be useful for regeneration therapies following injury to the heart.

By Leigh MacMillan
January 31, 2013

Nobel laureate explores genomics of immune response

In a wide-ranging lecture that moved from plants to nematode worms to human leukemia, Nobel laureate Andrew Fire, Ph.D., outlined his vision for a genomics-based understanding of how organisms respond to novel information.

By Leigh MacMillan
January 31, 2013

Do-it-yourself repair in the kidney

The kidney can mediate its own repair through proliferation of resident immune system cells.

By Leigh MacMillan
January 23, 2013

New view of DNA processing ‘hub’

Structural studies reveal a new framework for understanding a central player in DNA processing.

By Leigh MacMillan
January 21, 2013

HDL cholesterol impaired in kidney disease

HDL cholesterol is impaired in patients with chronic kidney disease – and may increase their cardiovascular disease risk.
By Leigh MacMillan
January 18, 2013

Seeing light receptor’s interactions

Understanding how the main receptor for light interacts with other signaling molecules may inform new pharmaceutical development.
By Leigh MacMillan
January 17, 2013

Nobel laureate Fire set to deliver upcoming Discovery Lecture

Nobel laureate Andrew Fire, Ph.D., will deliver the next Flexner Discovery Lecture on Thursday, Jan. 24.
By Leigh MacMillan
January 17, 2013

Study helps define pancreatic cancer’s cellular origins

Vanderbilt and University of California investigators have discovered the “cell of origin” for pancreatic ductal adenocarcinoma, a finding that could lead to early detection methods and new treatments.
By Leigh MacMillan
January 17, 2013

Zinc: a new antibiotic target?

It may be possible to fight hospital-acquired pathogens like Acinetobacter baumannii by targeting the bacterium’s need for the nutrient metal zinc.
By Leigh MacMillan
January 10, 2013

Simulated Mars mission reveals body’s sodium rhythms

Clinical pharmacologist Jens Titze, M.D., and colleagues have discovered that – in contrast to the prevailing dogma – human sodium levels fluctuate rhythmically with 7-day and monthly cycles.
By Leigh MacMillan
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