Leigh MacMillan

Linking oxygen, iron and red blood cells

The HIF oxygen-sensing pathway and its responses to low oxygen may be targeted for treatments of anemia and disorders of iron balance.

Brain tumor TIP reveals new target

The protein TIP-1 appears to be a novel prognostic marker for glioblastoma and may be a good therapeutic target for disrupting tumor-driven blood vessel development.

Cell source of heart’s blood vessels

An unexpected group of cells generates the coronary arteries and may be useful for regeneration therapies following injury to the heart.

Nobel laureate explores genomics of immune response

In a wide-ranging lecture that moved from plants to nematode worms to human leukemia, Nobel laureate Andrew Fire, Ph.D., outlined his vision for a genomics-based understanding of how organisms respond to novel information.

Do-it-yourself repair in the kidney

The kidney can mediate its own repair through proliferation of resident immune system cells.

New view of DNA processing ‘hub’

Structural studies reveal a new framework for understanding a central player in DNA processing.

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