Aliquots - Research Briefs

August 22, 2013

Overcoming resistance in ovarian cancer

The nuclear receptor TR3 contributes to ovarian cancer cell death in response to platinum-based chemotherapy – and may be a good target for overcoming cell resistance to certain treatments.

By Leigh MacMillan
August 14, 2013

Oxidative stress in autism

A biomarker for oxidative stress is elevated in patients with both autism spectrum disorder and gastrointestinal dysfunction, suggesting opportunities for individualized approaches to clinical care.

By Bill Snyder
August 12, 2013

Noninvasive test detects stomach bug

A noninvasive test can be used to identify the presence of Helicobacter pylori and evaluate its virulence, which will be useful in areas with high rates of H. pylori-associated gastric cancer.

By Leigh MacMillan
August 9, 2013

‘Yo-yo dieting’ inflames fat tissue

Gaining and losing weight during “yo-yo dieting” may contribute to an exaggerated immune response in fat tissue that increases metabolic dysfunction more than steady weight gain alone.

By Leigh MacMillan
August 8, 2013

Nuclear shield against cell death

The protein SARM appears to protect cells from inflammation-driven death by stabilizing the nuclear laminin scaffold.

By Bill Snyder
July 31, 2013

Factor’s role in long bone development

Insight into how the protein neurofibromin participates in the signaling pathway that produces the body’s long bones has implications for fracture healing in some patients.

By Leigh MacMillan
July 29, 2013

Motor protein revs up cell division

A motor protein that helps drive cell division may be a promising new target for cancer therapeutics.
By Leigh MacMillan
July 26, 2013

Reducing fatal rhythms after heart attack

Reducing heart muscle response to calcium could decrease the risk of fatal arrhythmias after heart attacks.
By Courtney M. Campbell
July 25, 2013

Visualizing data on network ‘maps’

The new web application NetGestalt will allow investigators to simultaneously visualize different types of data for the same gene – such as mutation, expression and modification.
By Leigh MacMillan
July 17, 2013

Probing roles of a cell death protein

Vanderbilt researchers have discovered new roles for a protein involved in cell death processes that are activated to prevent tumor-causing DNA mutations.
By Leigh MacMillan
July 15, 2013

Defining patient retention

Vanderbilt researchers propose guidelines for defining patient retention in clinical studies – an important parameter that affects study conclusions and program evaluations.
By Leigh MacMillan
July 12, 2013

Methods for imaging myelin loss

Certain MRI metrics can be used to assess myelin loss in multiple sclerosis, which is important for planning and monitoring therapy.
By Leigh MacMillan
July 11, 2013

Model for MADD mitochondrial disease

A zebrafish model of a severe mitochondrial disease will be useful for developing new therapeutic approaches.
By Leigh MacMillan
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