Mutations in a cell membrane transporter protein impair the integrity of the gut lining, contributing to chronic gastrointestinal distress for people with the mutations, Vanderbilt researchers report.

The number of pediatric infections caused by Clostridioides difficile (C. diff) decreased from 2013 to 2019, likely due to an increase in antibiotic stewardship programs and improved hospital contact protocols, Vanderbilt researchers found.

Vanderbilt researchers have identified a novel mechanism regulating social behavior: Neuropeptide Y signaling in the nucleus accumbens brain region.

Regulation of the enzyme Sirtuin 1 in blood vessel endothelial cells may drive altered metabolism and vascular dysfunction during sepsis, Vanderbilt researchers have discovered.

Vanderbilt epidemiologists found 32 blood metabolites associated with obesity and showed that adding these to traditional disease prediction models improves accuracy of determining Type 2 diabetes risk.

Blocking thromboxane-prostanoid receptor signaling protected animals from lung fibrosis in preclinical models, suggesting a new treatment for IPF — a chronic, progressive lung disorder that often kills within 3-5 years of diagnosis.

Vanderbilt investigators have found that aging induces chronic cellular stress in pancreatic beta cells, which could contribute to the development of diabetes as we age.