Department of Biochemistry

April 11, 2018

“Idling” cancer cells may return

Vanderbilt investigators have discovered that cancer treatment induces an “idling” state for cells, which could promote resistance to treatment.

By Bill Snyder
April 6, 2018

New view of the heartbeat

Structural views of the proteins that regulate the heartbeat may help improve existing treatments for cardiac arrhythmias.

By Sanjay Mishra
March 28, 2018

What protein is that?

An improved technology enables high-throughput protein identification in imaging mass spectrometry, aiding proteomics research.

By Leigh MacMillan
close up of mans arm as he receives chemotherapy infusion
March 14, 2018

Boehringer Ingelheim and Vanderbilt University expand partnership to develop novel treatment approaches for cancer

New agreement will pursue therapies targeting MCL1 (myeloid cell leukemia 1), which is highly prevalent in many difficult-to-treat cancers.

By Bill Snyder
ekg results
March 12, 2018

Long QT syndrome – revealed

Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders.

By Bill Snyder
busy intersection
March 8, 2018

Iron-sulfur “intersection”

Vanderbilt researchers have discovered an unanticipated link between sulfur and iron balance, pointing to a genetic basis for iron-deficiency anemia.

By Sanjay Mishra
February 22, 2018

Mitochondrial mutations and disease

New findings suggest that oxidative stress damages mitochondrial DNA, and they link this damage to a disease state.
By Sanjay Mishra
December 5, 2017

DNA damage repair: molecular insights

Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.
By VUMC News and Communications
October 12, 2017

A switch for autoimmunity

Vanderbilt investigators have discovered a class of compounds that inhibit a mediator of inflammation and autoimmune disorders, and that could pave the way for development of future therapies.
By VUMC News and Communications
September 29, 2017

Novel insights to antibiotic targets

New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.
By Leigh MacMillan
August 3, 2017

HDAC3 role in B-cell development

The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.
By Leigh MacMillan
July 25, 2017

Altered metabolism and disease

Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.
By VUMC News and Communications
July 20, 2017

Study identifies protein’s role in chemotherapy resistance

Researchers at Vanderbilt University Medical Center (VUMC) have discovered a protein that may lead to a new way to prevent resistance and improve outcomes for patients whose cancers have mutations in the tumor suppressor gene BRCA2.
By Bill Snyder
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