Department of Veterans Affairs

January 31, 2019

Cell death pathway implicated in bone marrow failure

Vanderbilt investigators have linked a specific form of programmed cell death to myelodysplastic syndrome, a type of bone marrow failure.

By Leigh MacMillan
January 17, 2019

Spalluto, Lewis to lead VA lung screening initiative

Lucy Spalluto, MD, assistant professor of Radiology and Radiological Sciences, and Jennifer Lewis, MD, MS, instructor in Medicine, have been selected to co-lead the Veterans Affairs — Partnership to increase Access to Lung Screening (VA-PALS) National Program Evaluation.

December 13, 2018

Lean vs. obese adipose tissue cells

A greater understanding of the mechanisms and cell types involved in returning adipose (fatty) tissue to the lean state may lead to more effective treatments for obesity.

By Bill Snyder
November 29, 2018

Lung cancer survival signal

A receptor thought to be a cell growth inhibitor actually sends pro-survival signals in small cell lung cancer and is a candidate biomarker for poor prognosis.

By VUMC News and Communications
November 8, 2018

Vitamin C protects brain from seizures

Brain ascorbate — vitamin C — is important for protecting the brain against seizures and cognitive decline in Alzheimer’s disease.

By Nora Foegeding
Cholesterol
November 8, 2018

Obesity negates beneficial drug effects

A drug that improves levels of “good” cholesterol may not be beneficial for obese individuals, Vanderbilt researchers have discovered.

By VUMC News and Communications
October 12, 2018

Targeting diabetic kidney disease

Pathways activated by the epidermal growth factor receptor may be attractive targets to treat diabetic kidney disease, according to new findings from Vanderbilt investigators.
By Sanjay Mishra
September 27, 2018

Fat tissue’s “iron sink”

Alyssa Hasty and colleagues demonstrated that immune cells called macrophages act in fat tissue to store iron and prevent iron toxicity.
By Sanjay Mishra
September 14, 2018

Diabetes drug may prevent cancer

The research suggests that metformin should be further studied clinically for the prevention of liver cancer.
By VUMC News and Communications
September 14, 2018

New histoplasmosis risk map

The new mapping approach, called suitability score mapping, should improve public health assessments and interventions for geographic-specific infections.
By Bill Snyder
August 16, 2018

YAP after acute kidney injury

Activation of the signaling protein YAP may be a target for treating acute kidney injury, which affects up to 20 percent of hospitalized patients.
By Sanjay Mishra
July 12, 2018

Team explores diabetes drug’s ability to treat RSV infection

A drug used to treat diabetes may point to new therapies for respiratory syncytial virus (RSV) bronchiolitis — inflammation and obstruction of the lungs’ small airways. A multi-disciplinary team of Vanderbilt investigators has demonstrated that liraglutide reduces the inflammatory response to RSV infection in a mouse model of the disease.
By Leigh MacMillan
July 2, 2018

SMAD4 clue to colon cancer

Loss of a gene that is part of the TGF-beta signaling pathway increased inflammation in the colon and was observed in half of human colitis-associated cancers.
By Bill Snyder