DNA damage

Madison Adolph, PhD, left, David Cortez, PhD, and Archana Krishnamoorthy are studying fundamental processes involved in DNA replication.
July 22, 2021

Researchers discover that protein switches functions to regulate DNA replication

Vanderbilt biochemists have discovered what the DNA damage response protein RADX does — and how it does it.

By Leigh MacMillan
August 6, 2020

The importance of estrogen cycles

Deborah Lannigan and colleagues identify a key regulator of the estrogen receptor and suggest that its downregulation by oral contraceptives may increase oxidative stress and DNA damage, a common cause of cancer.

By Sarah E. Glass
June 18, 2020

Probing DNA damage repair

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works.

By Leigh MacMillan
David Cortez, PhD, left, Petria Thompson, Katherine Amidon, Brandt Eichman, PhD, and colleagues are studying how a DNA repair pathway protein shields sites of damage to avoid mutations.
July 25, 2019

Team’s study reveals details of new DNA repair pathway

Investigators have discovered how a DNA repair pathway protein shields sites of damage to avoid mutations and maintain genome integrity.

By Leigh MacMillan
July 16, 2019

A critical factor for wound healing

Vanderbilt-Ingram Cancer Center scientists have discovered a role for a tumor suppressor protein in skin wound healing.

By Anivarya Kumar
Kareem Mohni, PhD, left, and David Cortez, PhD, have discovered a new DNA repair pathway that guards against genomic mutations.
February 28, 2019

Novel DNA repair mechanism preserves genome integrity: study

Biochemistry investigators at Vanderbilt have discovered a new DNA repair mechanism that prevents gene mutations during DNA replication.

By Leigh MacMillan
August 2, 2018

Genetic balancing act

New findings about proteins involved in DNA repair are important for understanding why some cancers are more or less resistant to certain therapies.
By Meredith Jackson
July 19, 2018

New player in DNA damage repair

New findings open opportunities to understand mechanisms of DNA repair for a toxic form of DNA damage.
By Leigh MacMillan
June 11, 2018

Confronting TB resistance

Vanderbilt researchers describe how certain tuberculosis treatments work and suggest these medications may overcome the threat of drug-resistant tuberculosis.
By Niyati Vachharajani
February 22, 2018

Mitochondrial mutations and disease

New findings suggest that oxidative stress damages mitochondrial DNA, and they link this damage to a disease state.
By Sanjay Mishra
December 5, 2017

DNA damage repair: molecular insights

Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.
By VUMC News and Communications
June 12, 2017

Repriming replication roadblocks

New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away.
By Sanjay Mishra
October 21, 2016

DNA damage response protein

Vanderbilt researchers have determined that a previously uncharacterized protein responds to DNA replication stress and has an essential role in maintaining the integrity of the genome.
By Bill Snyder
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