New findings about proteins involved in DNA repair are important for understanding why some cancers are more or less resistant to certain therapies.

New findings open opportunities to understand mechanisms of DNA repair for a toxic form of DNA damage.

Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.

Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair.

Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.

Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports.

Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.