DNA

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Mitochondrial mutations not random

A study of mitochondrial DNA mutations suggests they result from a process that selects for particular mutations in certain tissues.

DNA sequence

VU ‘crosslinks’ study sheds light on chemical toxicity

Vanderbilt researchers have characterized the chemical structures of a series of DNA-protein “crosslinks” that may lead to better ways to avoid the cancer-causing potential of environmental chemicals and prevent some drug toxicities.

VANTAGE point

Travis Clark, Ph.D., technical director of Sequencing in the VANTAGE core laboratories, shows a tour group how DNA fragments are loaded onto “flow cells” for reading by “next-generation” sequencing machines.

Study tracks genes involved in heart rhythm disorders

A team led by Vanderbilt University investigators has discovered two new genes — both coding for the signaling protein calmodulin — associated with severe early-onset disorders of heart rhythm.

New view of DNA processing ‘hub’

Structural studies reveal a new framework for understanding a central player in DNA processing.

Carcinogenic chemicals cramp DNA

Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.

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