DNA

June 18, 2020

Probing DNA damage repair

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works.

By Leigh MacMillan
February 6, 2020

New tool probes gene regulation

Vanderbilt biochemists got unexpected results when they used their new approach to explore the role of DNA methylation in gene regulation.

By Leigh MacMillan
October 21, 2019

Completing DNA synthesis

James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis.

By Leigh MacMillan
March 14, 2019

Correctly copying DNA

A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.

By Sanjay Mishra
January 17, 2019

DNA’s on/off switch

DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.

By Bill Snyder
January 3, 2019

Vanderbilt experts discuss potential of universal genetic database to balance privacy, law enforcement concerns

The pivotal role that long distance familial genetic searches played in the apprehension of the notorious Golden State Killer — and as a tool in dozens more cases since — has led experts from Vanderbilt University and Vanderbilt University Medical Center to make a provocative proposal about how investigative use of DNA should be regulated.

By Holly Fletcher
July 19, 2018

New player in DNA damage repair

New findings open opportunities to understand mechanisms of DNA repair for a toxic form of DNA damage.
By Leigh MacMillan
March 15, 2018

Study spots undiagnosed genetic diseases in EHR

Patients diagnosed with heart failure, stroke, infertility and kidney failure could actually be suffering from rare and undiagnosed genetic diseases.
By Craig Boerner
September 29, 2017

Novel insights to antibiotic targets

New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.
By Leigh MacMillan
February 23, 2017

Team identifies ‘switch’ involved in DNA replication  

DNA replication is an extraordinarily complex multi-step process that makes copies of the body’s genetic blueprint. It is necessary for growth and essential to life. Now researchers at the California Institute of Technology (Caltech) and Vanderbilt University have found evidence that one of those steps may involve the telephone-like transmission of electrical signals regulated by a chemical “switch.”
By Bill Snyder
January 24, 2017

Saliva test for obesity risk

“Epigenetic signatures” in DNA may present an opportunity for prevention of or early intervention in childhood obesity.
By Bill Snyder
October 7, 2016

Rheumatoid subtypes explored by PheWAS

A computer-based method pioneered at Vanderbilt is being used to compare subtypes of rheumatoid arthritis.
By Paul Govern
April 15, 2016

Mechanism of a DNA repair protein

Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.
By Sanjay Mishra
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