DNA

model of DNA double helix

Faulty building blocks in DNA

An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

DNA sequence visualization

Study helps clarify components of DNA ‘copy machine’

Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.

DNA image

New class of DNA repair enzyme discovered

A new class of DNA repair enzyme has been discovered which demonstrates that a much broader range of damage can be removed from the double helix in ways that biologists did not think were possible.

Repair protein’s DNA recognition motif

Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

(iStockphoto.com)

Mitochondrial mutations not random

A study of mitochondrial DNA mutations suggests they result from a process that selects for particular mutations in certain tissues.

DNA sequence

VU ‘crosslinks’ study sheds light on chemical toxicity

Vanderbilt researchers have characterized the chemical structures of a series of DNA-protein “crosslinks” that may lead to better ways to avoid the cancer-causing potential of environmental chemicals and prevent some drug toxicities.

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