DNA

model of DNA double helix
January 22, 2016

Faulty building blocks in DNA

An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

By Bill Snyder
DNA sequence visualization
November 12, 2015

Study helps clarify components of DNA ‘copy machine’

Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.

By Leigh MacMillan
DNA image
October 29, 2015

New class of DNA repair enzyme discovered

A new class of DNA repair enzyme has been discovered which demonstrates that a much broader range of damage can be removed from the double helix in ways that biologists did not think were possible.

By Leigh MacMillan
May 23, 2014

Repair protein’s DNA recognition motif

Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

By Leigh MacMillan
(iStockphoto.com)
November 25, 2013

Mitochondrial mutations not random

A study of mitochondrial DNA mutations suggests they result from a process that selects for particular mutations in certain tissues.

By Leigh MacMillan
DNA sequence
October 31, 2013

VU ‘crosslinks’ study sheds light on chemical toxicity

Vanderbilt researchers have characterized the chemical structures of a series of DNA-protein “crosslinks” that may lead to better ways to avoid the cancer-causing potential of environmental chemicals and prevent some drug toxicities.

By Bill Snyder
April 25, 2013

VANTAGE point

Travis Clark, Ph.D., technical director of Sequencing in the VANTAGE core laboratories, shows a tour group how DNA fragments are loaded onto “flow cells” for reading by “next-generation” sequencing machines.
By VUMC News and Communications
February 7, 2013

Study tracks genes involved in heart rhythm disorders

A team led by Vanderbilt University investigators has discovered two new genes — both coding for the signaling protein calmodulin — associated with severe early-onset disorders of heart rhythm.
By Leigh MacMillan
January 23, 2013

New view of DNA processing ‘hub’

Structural studies reveal a new framework for understanding a central player in DNA processing.
By Leigh MacMillan
November 21, 2012

Carcinogenic chemicals cramp DNA

Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.
By VUMC News and Communications
November 1, 2012

Genomic research gains ad-“vantage” with new resources

Vanderbilt University Medical Center has stepped up its support of research aimed at cracking the mysteries of the genome, the master DNA code.
By Bill Snyder
October 11, 2012

VU recruit’s work lights up genetic ‘dark matter’

They’ve been called “junk DNA” and genetic “dark matter” — the long segments of the human genome (98 percent of it) that do not encode protein.
By Bill Snyder
September 6, 2012

BioVU reaches new benchmark in DNA samples

This month BioVU logged in its 150,000th unique genetic sample. It is now the world’s largest collection of human DNA linked to searchable, electronic health information.
By Bill Snyder
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