drug resistance

bacteria microbiome
February 5, 2016

Dynamics of a drug resistance transporter

Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance.

By VUMC News and Communications
December 10, 2015

New lead for ovarian cancer treatment

Combining inhibitors of the BMP signaling pathway with standard chemotherapy drugs may overcome drug resistance in ovarian cancer.

By VUMC News and Communications
November 4, 2015

Detect and defend against pathogens

Understanding factors, such as the receptor TLR9, that detect and defend against pathogens may lead to therapeutic approaches that promote an effective immune response to treat infections.

By Leigh MacMillan
February 10, 2015

Targeting HIV’s “cap”

New findings underscore the attractiveness of the HIV capsid – the structure that encloses the viral genome – as a therapeutic target.

By VUMC News and Communications
October 29, 2014

Key to prostate cancer resistance

A combination of two types of therapy may be more effective in treating castration-resistant prostate cancer.

By VUMC News and Communications
June 13, 2014

How ABC transporters move molecules

New views of how transporters move molecules across cell membranes are key to understanding how these proteins impact tumor cell drug resistance and inherited diseases such as cystic fibrosis.

By Leigh MacMillan
March 3, 2014

Dismantling staph’s drug resistance

Targeting the enzyme FosB could make antibiotic-resistant staph bacteria sensitive to the antibiotic fosfomycin.
By Leigh MacMillan
December 12, 2013

Proton transfer powers multidrug resistance: study

Vanderbilt University researchers and their Belgian colleagues have discovered the mechanism behind a multidrug transporter. Their findings, posted this week by Nature Chemical Biology, could lead to new treatments for multidrug resistant bacterial infections.
By VUMC News and Communications
September 12, 2013

VU study identifies DNA changes in drug-resistant cancer cells

Vanderbilt investigators have combined next-generation sequencing technologies and bioinformatics analyses to screen for genome-wide genetic mutations associated with drug resistance in a series of lung cancer cell lines.
By Leigh MacMillan
August 22, 2013

Overcoming resistance in ovarian cancer

The nuclear receptor TR3 contributes to ovarian cancer cell death in response to platinum-based chemotherapy – and may be a good target for overcoming cell resistance to certain treatments.
By Leigh MacMillan
September 21, 2012

HER2 may impact lung cancer therapy

A protein associated with aggressive breast cancers may also influence resistance of lung cancer to targeted therapies.
By VUMC News and Communications