GWAS

February 1, 2024

A biomarker for early Type 2 diabetes

Genetic analyses suggest that branched chain amino acids may be a sensitive biomarker of early or subclinical Type 2 diabetes and could be used to identify risk and implement preventive measures.

By Bill Snyder
August 31, 2023

New reference tool supports replication of DNA biobank studies

Vanderbilt researchers created a phenotype-genotype reference map to assess data quality in DNA biobanks.

By Paul Govern
February 16, 2023

Breast cancer genetics: new insights

Largest genetic study of breast cancer to date identifies 222 genetic risk loci, 137 genes and multiple signaling pathways associated with risk, providing important new insights.

By Leigh MacMillan
(iStock)
November 30, 2021

Study examines genetic risk for suicide attempt

New research from Vanderbilt identifies the first replicated genomic region contributing to risk of suicide attempt and confirms that genetic risk for the trait is not driven solely by risk for psychiatric disorders.

By Paul Govern
September 30, 2021

Study shows how a protein coding gene confers breast cancer susceptibility during DNA transcription

Vanderbilt-Ingram Cancer Center research is providing new insights into how genetic variants convey breast cancer susceptibility by altering the transcription factor proteins that convert DNA strands into RNA.

By Tom Wilemon
June 17, 2021

Drug allergy labels in medical records power searches for gene-drug associations

By Paul Govern
October 22, 2020

New tool to probe genetic mechanisms of disease

Vanderbilt Genetics Institute investigators have added a new method to the computational genetics toolbox. Their approach, described in the journal Nature Genetics, integrates vast genomics datasets to predict gene expression and facilitate discovery of genetic mechanisms underlying human diseases.
By Leigh MacMillan
October 1, 2020

Genes spell penicillin allergy risk

Studies using large DNA biobanks revealed genetic variants associated with penicillin allergy, the most common type of drug-induced allergic reaction.
By Paul Govern
September 19, 2019

Potential prostate cancer biomarkers

An analysis of more than 140,000 people of European ancestry has identified blood protein biomarkers associated with prostate cancer risk.
By Leigh MacMillan
August 26, 2019

Cancer susceptibility genes

Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations.
By Leigh MacMillan
January 10, 2019

Study identifies novel genetic factors for colorectal cancer risk

A large-scale study conducted among East Asians and led by Vanderbilt researchers has identified multiple, previously unknown genetic risk factors for colorectal cancer.
By Tom Wilemon
October 1, 2018

Probing the genetics of fibroids

A new study identified multiple genetic locations associated with the size and number of uterine fibroids — common non-cancerous uterine tumors.
By Leigh MacMillan
August 2, 2018

Connecting an asthma gene to leukemia

A receptor previously implicated in asthma may also play roles in other allergic diseases and in leukemia, Vanderbilt researchers have discovered.
By Leigh MacMillan