immunity

Enhancing innate immunity in the lung

Vanderbilt researchers show that a TLR4 agonist improves lung immune response and survival in a mouse model of bacterial pneumonia, supporting the development of this drug to protect against pneumonia in hospitalized patients.

Ayaka Sugiura and Jeff Rathmell, PhD, are studying a metabolic enzyme involved in T cell function that may offer a new target for anti-inflammatory therapeutics.

CRISPR screen identifies new anti-inflammatory drug target

A novel CRISPR screen developed by Vanderbilt researchers identified a promising new target for anti-inflammatory therapeutics.

Rational vaccine design

Understanding immunity generated by smallpox vaccine may hold lessons for COVID-19 vaccine development.

Antibody mixture may help block Ebola virus infection

A research team led by scientists at Vanderbilt University Medical Center has developed an antibody mixture that in animals is highly effective in blocking infection by the Ebola virus.

RNA processing and antiviral immunity

John Karijolich and colleagues have discovered a link between cellular RNA processing and the innate cellular immune response to viral pathogens.

Team finds potent antibodies against three Ebola viruses

Researchers at Vanderbilt University Medical Center and their colleagues are a step closer to developing a broadly effective antibody treatment against the three major Ebola viruses that cause lethal disease in humans.