Excess dietary salt activates immune cells to induce inflammation and hypertension, supporting current recommendations for low sodium consumption.

A single mutation in one gene can impair inhibitory signaling in the brain and cause multiple types of seizures and behavioral abnormalities.

A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections.

Danny Winder and colleagues are teasing apart the actions of neurotransmitter receptors in a brain region linked to anxiety and addiction, with a goal of finding treatments for substance use disorders.

Roger Colbran and colleagues have discovered new molecular details about the function of an enzyme with a key role in shaping learning and memory.

A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered.

Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles.