How to get the biggest “bang” for the research “buck”

Vanderbilt researchers are developing new methods to maximize what can be learned from clinical trials and cohort studies, while maintaining their rigor and reproducibility.

Tracking lung macrophages

A new technique will allow researchers to track subsets of immune cells that patrol and defend the lungs, to better understand the roles of these cells during lung inflammation, infection and injury.

COVID alters respiratory microbiota

COVID-19 infection alters the microbes of the upper respiratory tract for at least several weeks, and such disturbances could impact disease severity and be targets for therapeutic interventions.

Genetics and chronic pain

Polygenic risk scores — scores that reflect the influence of common genetic variants — could be used to predict the likelihood of developing chronic overlapping pain conditions and guide biomarker and targeted prevention efforts.

The problem with the problem list

Algorithms to infer missing problems and suggest that they be added to electronic health records improved problem list completeness, with benefits for clinical care, patient comprehension of health conditions and population health.

The study found that increasing number of steps taken each day can steps taken daily can reduce the risk of several common, chronic diseases. (istock image)

COVID-19’s lingering impact on health

A decline in cardiovascular fitness — measured by activity trackers in the All of Us research program — persisted among some groups even after COVID-related restrictions were relaxed, exacerbating health disparities.

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