NIGMS

January 13, 2016

Platelet protein modification

Vanderbilt investigators have identified a new biomarker to assess platelet function.

By Leigh MacMillan
blood cells
January 7, 2016

Immune tolerance in endothelial cells

Inducing “tolerance” to bacterial toxins in the endothelial cells that line blood vessels may offer a new approach for preventing the negative consequences of sepsis.

By Leigh MacMillan
green traffic light
December 3, 2015

Microtubules act as cellular ‘rheostat’ to control insulin secretion

Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell.

By Leigh MacMillan
October 16, 2015

Healing without scarring

Drugs that inhibit the Wnt signaling pathway can regenerate injured skin and may be useful in treating fibromatosis, degenerative joint disease and cancer.

By Sanjay Mishra
October 2, 2015

The yin and yang of COX-2

New findings add to the understanding of how the enzyme COX-2 works, which is critical to the development of COX-2-targeted anti-inflammatory drugs.

By Sanjay Mishra
conceptual - glowing cell
October 1, 2015

Tolerating a transplant

A new genetic model has generated new strategies for promoting tolerance to transplants – and improving long-term transplant outcomes – in the background of autoimmune disease.

By Leigh MacMillan
September 23, 2015

Data diving for health

To most effectively use electronic health records for research, investigators should query multiple components of the record to identify patients with specific diseases.
By VUMC News and Communications
July 27, 2015

Anticancer olive compounds

Compounds found in olives and olive oil have anticancer activity, which may contribute to the cancer preventive properties attributed to the Mediterranean diet.
By Leigh MacMillan
July 15, 2015

Drug signaling networks

Vanderbilt investigators have developed a new algorithm to understand the networks of signaling molecules that control drug action.
By Leigh MacMillan
July 13, 2015

Hhex on cancer

A new mouse model demonstrates that the Hhex gene – which is linked to blood cancers – is critical for normal blood cell production.
By Henry H. Ong
June 16, 2015

A view of brain function in disease

Vanderbilt investigators report the first use of a specialized type of MRI to study the hippocampus in patients with schizophrenia.
By Leigh MacMillan
May 15, 2015

Boosting cell-based heart repair

A metabolic change in adult stem cells makes them less “fit” for regenerative heart therapies, suggesting that strategies to prevent this response may boost the therapeutic usefulness of the cells.
By Leigh MacMillan
May 6, 2015

Neurofibromin fine-tunes bone growth

The protein neurofibromin acts as a brake in a signaling pathway that is important in bone development, Vanderbilt researchers have discovered.
By Leigh MacMillan
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