NIGMS

May 1, 2015

New player in neuronal communication

Vanderbilt researchers have discovered a novel mechanism for the development of dendritic spines – sites of nerve cell communication.

By Leigh MacMillan
April 30, 2015

Team tracks how kidney responds to blood pressure meds

Changes in the kidney can limit the blood pressure-lowering effects of thiazide diuretics, a new study reports.

By Leigh MacMillan
April 2, 2015

Aging insights from budding yeast

The proteins that control entry and exit from the cell nucleus influence aging, Vanderbilt researchers have discovered.

By Leigh MacMillan
February 25, 2015

Antibiotics with anticancer potential

A series of experimental antibiotics may be a good starting point for developing new anticancer drugs.

By Leigh MacMillan
February 19, 2015

‘Stretched’ cells promote cancer

Mechanical stress appears to be a critical factor in activating normal tissue-associated fibroblasts to generate cancer-associated fibroblasts.

By Leigh MacMillan
February 9, 2015

Gene profile predicts metastasis

A specific gene expression profile represents a novel, biologically relevant “signature” for identifying colon cancers with high risk of metastatic recurrence, Vanderbilt researchers have found.

By Yan Su
February 5, 2015

Copper toxicity and Parkinson’s

A genetic predisposition to Parkinson’s disease makes neurons more vulnerable to the toxicity of heavy metals such as copper.
By Leigh MacMillan
January 28, 2015

New clue to a devastating disease

New findings suggest a previously unrecognized role for the Sox10 transcription factor in Hirschsprung’s disease, and may lead to improved diagnostic and therapeutic approaches for this disease.
By Bill Snyder
January 26, 2015

Immune response depends on force

New studies explain how T-cell receptors use force to recognize and protect us against pathogens.
By Leigh MacMillan
January 8, 2015

Enzyme affects tumor metastasis

A protein that degrades the “matrix” between cells participates in the development of lung metastases from primary breast cancer in mouse models and may be a good target for breast cancer treatment.
By Daren Diiorio
December 18, 2014

Atrial disease and hypertension links

New findings suggest that misfolded proteins accumulate in the heart atria, particularly in patients with hypertension, and may contribute to atrial heart disease.
By Leigh MacMillan
December 16, 2014

Retinal neuron survival in glaucoma

Understanding how the protein TRPV1 helps neurons survive after glaucoma-related stressors could lead to new therapeutic strategies for glaucoma and other neurodegenerative conditions.
By Leigh MacMillan
November 26, 2014

New tools to probe manganese biology

Vanderbilt researchers have developed tools to probe the role of the essential metal manganese in neurons, and which offer a started point for developing therapeutic agents for manganese-related neurological disorders.
By Leigh MacMillan
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