NIH

Cellular forces aid tumor invasion

The contractile machinery inside tumor cells increases invasive properties, suggesting it might be a good target to inhibit cancer cell spread.

Insulin in vials

CaMKII enhances insulin secretion

The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion.

Heart illustration thumbnail

Normalizing calcium flux to treat atrial fibrillation

A particular anti-arrhythmia drug provides a targeted treatment for certain forms of atrial fibrillation.

Bypassing DNA damage

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

PET probe detects dying tumor cells

A novel PET imaging probe detects tumor cell death in vivo and could be useful for personalizing cancer medicine.

Potential mechanism for myeloma drug’s variable toxicity

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.

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