seizures

VUMC implants first patient in NAUTILUS study for treatment of idiopathic generalized epilepsy

A Vanderbilt patient with idiopathic generalized epilepsy is now the first to receive neuromodular stimulation of the brain to see if it can help with seizures.

Sudden death from deep in the brain?

Vanderbilt neurologists found altered excitability in deep brain structures that they note may drive respiratory dysfunction and sudden death in a rare form of epilepsy.

Functional seizures associated with stroke, psychiatric disorders in electronic health records study

In a large-scale study of electronic health records, Vanderbilt University Medical Center investigators have determined the prevalence of functional seizures and characterized comorbidities associated with them.

brain and lightning

Single mutation causes seizure disorder

A single mutation in one gene can impair inhibitory signaling in the brain and cause multiple types of seizures and behavioral abnormalities.

A new anti-seizure target?

Vanderbilt neurologists have identified a protein modification that could be targeted to reduce neuronal excitability in epilepsy.

Study reveals mysteries of critical brain receptor complex

Poorly functioning AMPARs have been linked to a wide range of neurological and psychiatric disorders including seizures, Alzheimer’s disease, major depression and autism spectrum disorder. Understanding how AMPARs are formed and operate is essential for the rational design of pharmacological compounds that, by tuning AMPAR activity up or down, could improve treatment of these conditions.

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