zebrafish

January 13, 2020

Vanderbilt-led team discovers new genetic disease and defines underlying mechanism

An international research team has discovered a new genetic syndrome caused by mutation of a single gene and named it CATIFA, an acronym for its core symptoms.

By Leigh MacMillan
September 5, 2019

Zebrafish aid effort to regenerate damaged retinas

According to a new study, the tiny zebrafish may hold the secret to regenerating damaged retinas in humans.

By Bill Snyder
April 24, 2019

Study merges big data and zebrafish biology to reveal mechanisms of human disease

In a series of studies that volleyed between large databases and research in zebrafish, Vanderbilt investigators have discovered a link between vascular biology and eye disease.

By Leigh MacMillan
eye
January 25, 2018

A cataract-heart connection

Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease.

By Meredith Jackson
March 8, 2016

Fat hormone’s role in zebrafish

The hormone leptin regulates glucose balance, but not fat stores, in zebrafish.

By Leigh MacMillan
July 29, 2015

In a zebrafish’s eye

Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts.

By Sanjay Mishra
June 11, 2015

A “CRISPR” way to study disease

Using revolutionary CRISPR technology, Vanderbilt investigators have developed a fast and simple method to simultaneously turn off multiple genes in order to study complex diseases.
By VUMC News and Communications
April 23, 2015

VU team explores new cholesterol processing pathway

A zebrafish model of a rare genetic disease has revealed an unexpected regulatory pathway for cholesterol absorption and processing.
By Leigh MacMillan
April 3, 2015

Cancer signaling pathway blocker

Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer.
By VUMC News and Communications
February 20, 2015

Tiny model of diabetes

Vanderbilt University researchers have created a zebrafish model of skeletal muscle insulin resistance that could help improve diabetes treatment.
By Bill Snyder
December 18, 2013

Targeting tumor “supply lines”

A metabolic enzyme plays a crucial role in vascular development and may be a good target for cancer therapies.
By Leigh MacMillan
September 18, 2013

Fishing for new anti-cancer drugs

Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug.
By Leigh MacMillan
July 11, 2013

Model for MADD mitochondrial disease

A zebrafish model of a severe mitochondrial disease will be useful for developing new therapeutic approaches.
By Leigh MacMillan