Genetics & Genomics

December 19, 2024

Proteomic signature a key to early detection of fatty liver disease: study

Currently, methods to detect early, obesity-related accumulation of fat in the liver other than a liver biopsy — the surgical removal of liver tissue for microscopic examination — are limited. But there is hope.

By Bill Snyder
December 18, 2024

VUMC part of multisite team investigating genetic markers of anorexia nervosa

With funding from the newly established Sarah Kyle Anorexia Nervosa Research Foundation, the researchers hope to identify biomarkers that will point to novel targets for prevention and treatment.

By Leigh MacMillan
December 10, 2024

Study identifies that higher West African ancestry may contribute to worse breast cancer outcomes 

The study found that West African genetic ancestry was associated with shorter disease-free survival, particularly for women with hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer.

By Tom Wilemon
Members of the Kang lab include (front row from left) Melissa Deleeuw, Jing-Qiong (Katty) Kang, MD, PhD, Wangzhen Shen, MD, and Karishma Randhave, and (back row from left) Ekta Anand, Debbie Song, and Kirill Zavalin, PhD. (photo by Susan Urmy)
December 10, 2024

Therapy for genetic epilepsy in children showing promise

Preliminary results of a clinical trial of 4-phenylbutyrate (PBA) “show a significant reduction in seizure activity among participants.”

By Bill Snyder
(iStock)
November 27, 2024

Vanderbilt scientists discover shared genetic foundations between musical rhythm and human language

The study revealed overlapping genetic underpinnings between rhythm-related skills and language-related traits, including dyslexia.

By Danny Bonvissuto
November 26, 2024

Novel genetics approach enhances discovery of disease risk genes

VUMC researchers applied the new approach to large GWAS datasets for breast, prostate and lung cancers, and three brain disorders.

By Leigh MacMillan
November 25, 2024

Potential treatment eyed for abnormal blood cell disorder

Research could lead to improved diagnosis and the first effective treatment for the disorder, called “clonal hematopoiesis of indeterminant potential,” or CHIP. 
By Bill Snyder
October 30, 2024

Genetic risk, sexual trauma associated with mental illness: study

Evaluating how genetic risk interacts with environmental risk factors such as sexual trauma is important for understanding how mental illness develops and identifying high-risk groups for early intervention.
By Leigh MacMillan
October 25, 2024

Blockbuster obesity drugs also may slow kidney disease

The report supports previous clinical trials that found the GLP-1 receptor agonist drug semaglutide reduced kidney disease progression in patients with Type 2 diabetes.
By Bill Snyder
October 22, 2024

VUMC, Nigeria teaching hospital to study genetic risk of fibroids based on regional African ancestry

The research team will analyze existing genome-wide association study data and RNA sequencing to compare fibroid development patterns in Nigerian women and U.S. Black women, which could point to targeted therapies and management strategies for affected women.
By Kristin Centers
October 18, 2024

All of Us tour stops at VUMC Oct. 22-25

The All of Us Research Program brings the future of health to VUMC and Nashville. 
October 7, 2024

Kimberlyn Ellis selected as 2024 Vanderbilt Prize Student Scholar

Ellis is a computational geneticist with a long-term goal of bridging genomics, bioethics and health policy to promote equitable precision medicine for minority populations.
By Leigh MacMillan
September 27, 2024

Distant relatedness in biobanks harnessed to identify undiagnosed genetic disease

VUMC researchers have developed a genetic method that clusters distantly related people to find rare variants that were present in a common ancestor.
By Leigh MacMillan
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