Genetics & Genomics

Tishkoff's groundbreaking research at the University of Pennsylvania has broad implications for understanding and treating human disease.

The research could point to future therapeutic strategies that treat PF patients based on their individual stage of cellular and molecular remodeling.

The study identified 332 independent association signals for breast cancer risk, including 131 signals not previously reported.

The study sets out how gene expression that drives the formation of new blood vessels exhibits different patterns, cell by cell, in the brains of people with Alzheimer's disease.

Currently, methods to detect early, obesity-related accumulation of fat in the liver other than a liver biopsy — the surgical removal of liver tissue for microscopic examination — are limited. But there is hope.

With funding from the newly established Sarah Kyle Anorexia Nervosa Research Foundation, the researchers hope to identify biomarkers that will point to novel targets for prevention and treatment.

The study found that West African genetic ancestry was associated with shorter disease-free survival, particularly for women with hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer.