biomarkers

December 3, 2025

Large-scale integration of genomics, proteomics and clinical records identifies cancer risk proteins and potential therapeutics

A new study identifies previously unreported protein biomarkers and candidate drug targets across six major cancer types and highlights approved drugs with potential cancer preventive effects.

By Leigh MacMillan
November 6, 2025

Inflammatory marker could predict response to therapy in bladder pain syndrome

Patients with chronic bladder pain syndrome who had higher baseline levels of the inflammatory molecule IL-1beta had greater overall improvement following cognitive behavioral therapy.

By Georgia Caso
November 8, 2024

People with schizophrenia show distinct brain activity when faced with conflicting information

Researchers introduce a biomarker to indicate whether someone is struggling with the inflexible thinking associated with the disorder.

By Joseph Caputo
Photo caption: Jonathan Mosley, MD, PhD, left, Scott Borinstein, MD, PhD, John Shelley, and Vivian Kawai, MD, MPH, are studying how genetic variation not related to disease affects clinical decisions. (photo by Susan Urmy)
June 3, 2024

Genetic variation associated with low white blood cell count impacts clinical decisions

People whose white blood cell levels are near the edge of the “healthy” reference range will hit a clinical decision point that has consequences such as diagnostic procedures and altered treatments.

By Leigh MacMillan
May 7, 2024

Study seeks to evaluate military exposures on veterans’ lung cancer risk 

A prospective cohort of veterans including those with military toxic exposures, such as burn pits, will be screened annually with low-dose chest CT to detect lung cancer and other disease early.

By Tom Wilemon
May 2, 2024

The big sort 

A new interactive tool presents information on noncoding RNA in extracellular vesicles — agents of cell-cell communication that may have a future in medical diagnosis and therapeutics.

By Paul Govern
April 18, 2024

New urine test has higher diagnostic accuracy for prostate cancer

Prostate cancer is the most common cancer and the second leading cause of cancer death among men in the U.S.
By Tom Wilemon
March 7, 2024

Study details metabolism of biomarkers for oxidative stress

Factors other than oxidative stress can modify the levels of biomarkers called isoprostanes that are commonly used in both experimental and clinical research, suggesting that additional standards need to be developed.
By Leigh MacMillan
February 1, 2024

A biomarker for early Type 2 diabetes

Genetic analyses suggest that branched chain amino acids may be a sensitive biomarker of early or subclinical Type 2 diabetes and could be used to identify risk and implement preventive measures.
By Bill Snyder
April 6, 2023

A ‘supermere’ method for biomarker discovery

Vanderbilt researchers have developed a method for isolating extracellular vesicles and nanoparticles — a complex transport system involved in health and disease — which will improve biomarker discovery and the identification of therapeutic targets.
By Bill Snyder
March 27, 2023

Improving lung nodule diagnosis

Adding blood and imaging biomarkers to a clinical prediction model could improve diagnostic accuracy for the 1.6 million lung nodules detected each year, many through expanded lung cancer screening programs.
By Leigh MacMillan
January 9, 2023

Novel lung cancer biomarker

Autoantibodies against the p53 tumor suppressor protein may be a novel biomarker for identifying people, especially African Americans, at high risk for lung cancer.
By Leigh MacMillan
November 17, 2022

A marker for mortality

A urine biomarker of inflammation was associated with increased mortality and multiple lifestyle factors, suggesting that modifications could help reduce premature mortality.
By Sarah E. Glass
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