A Vanderbilt study of genetic risks for cognitive impairment later in life uses data from 32,426 research participants ages 60 and older to elaborate these risks across sex and across the intersection of sex and race.

MRI brain scans at baseline for study participants 60 and older — who were free of clinical dementia at study entry — predicted a decline in independent function five years later.

A sweet spot in the deep brain with direct lines of communication to motor regions far out on the cerebral cortex might hold a key to halting the progression of early-stage Parkinson’s disease.

Vanderbilt researchers used novel MRI methods to noninvasively quantify measures of neurofluid circulation and found that hypertrophy of a site of cerebrospinal fluid egress may be related to amyloid-beta retention in Alzheimer’s disease.

A machine learning method based on neural networks outperformed a mutational scanning model at identifying disease-causing mutations in an Alzheimer’s disease protein, suggesting the method could be useful for facilitating therapeutic design.

Vanderbilt research shows a common anesthesia drug could be beneficial in reducing pressure inside the skull of children with traumatic brain injuries.

Photoperiod, or length of day, has sex-specific impacts on dopamine dynamics in the brain, offering insights into sex differences in neuropsychiatric disorders, Vanderbilt researchers report.