Division of Nephrology and Hypertension

The brain’s response to low oxygen — growth and remodeling of blood vessels — involves certain cell types and molecular pathways, Vanderbilt researchers have discovered.

Vanderbilt researchers have identified a signaling pathway that promotes kidney fibrosis in patients with diabetes — and that could be targeted with an existing approved medication.

A protein linked to amyotrophic lateral sclerosis (ALS), a progressive neurological disease that causes muscle weakness, may be a key to treating fibrotic disease of the kidneys and other organs, researchers at Vanderbilt University Medical Center reported recently.

A $500,000 KidneyX prize has been awarded to The Kidney Project — a collaboration between Vanderbilt University Medical Center and University of California, San Francisco (UCSF) — for the development of an implantable dialysis system that would enable patients to safely and effectively treat kidney failure at home.

Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it.

Vanderbilt researchers used pharmacological manipulations to increase salt and water transport by kidney cells grown in culture, a step necessary for realizing an implantable artificial kidney device.

William J. Stone, MD, nephrologist and professor of Medicine, emeritus, who retired in December after 50 years as a member of the faculty of the Vanderbilt University School of Medicine, died Monday, May 11, at his home in Nashville. He was 83.