Epithelial Biology Center Archive — Page 1 of 3

Medical illustration of a colonoscope inside the bowel, positioned beside a small polyp being removed with a wire loop.
September 2, 2026

‘Balancing act’ helps keep colorectal cancer in check

Vanderbilt Health study offers potentially new avenues to explore in the treatment of colorectal cancer.

Multiplex immunofluorescence comparison of mouse small-intestinal tissue, showing elongated villi in the left panel and shorter, irregular villi with denser fluorescent labeling in the right panel. A color legend lists markers including SGLT1, EPCAM, PEGFR, ACTG1, DCLK1, CHGA, 5-HT, TFF3, Ki67, pHH3, 24h-EdU, OLFM4, LY Z, Collagen, YFP, and Nuclei.
March 18, 2026

Motor protein plays key role in intestinal stem cell identity, function

Study findings suggest a new therapeutic approach for a rare digestive disorder, microvillus inclusion disease.

3D medical illustration showing a colonoscope, a long flexible tube, inserted through the rectum and threaded through the colon.
September 8, 2025

SPORE grant funds $12 million for colorectal cancer research

SPORE grants are highly sought after because they show that a cancer center demonstrates scientific excellence, promotes collaboration, maintains robust research programs and merits substantial funding.

Ken Lau, PhD, left, and Bob Coffey, MD, have made several important discoveries about colorectal cancer that are aiding the search for new, more effective therapies. (photo by Erin O. Smith)
December 11, 2023

Colorectal cancer ‘cartography’ reveals an avenue to improved immunotherapy

Vanderbilt University Medical Center researchers have discovered why most colorectal tumors escape detection and destruction by the body’s immune system.

Close-up 3D rendering of densely packed pink, rounded finger-like biological structures, with larger forms in the foreground and smaller ones receding into the background.
July 12, 2022

Probing the tumor microenvironment

Vanderbilt researchers used single-cell sequencing, imaging, and computational approaches to characterize the colonic tumor microenvironment, providing important insights to the components that play roles in colorectal tumor pathogenesis.

Stomach
May 19, 2022

Molecular ‘switch’ may illuminate stomach disorders

An international team that included researchers from Vanderbilt University Medical Center has discovered a molecular switch that induces rapid proliferation of zymogen granule-secreting chief cells in the stomach to regenerate damaged tissue.