JCO Precision Oncology (journal)

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Inherited gene elevates prostate cancer risk in affected families

The inherited mutated gene WNT9B, which functions normally in embryonic prostate development, increases risk of adult prostate cancer.

photo of William Dupont

Study discovers that tumor mutation burden predicts survival outcome

The expected course of a patient’s cancer prognosis has traditionally been judged by its type, stage and microscopic aggressiveness, but patients with the same presentation can still have widely divergent outcomes. Researchers from Vanderbilt-Ingram Cancer Center have discovered that differences in tumor mutation burden are a major reason for this divergence.

Cell-free breast cancer “biopsy”

The circulating DNA that tumors release is a reliable metric of tumor genomics and can be used to monitor molecular changes in metastatic breast cancer.