Antibody research may lead to broadly protective flu vaccine

These findings could lead to the development of cross-reactive and neutralizing antibody therapies for individuals who are severely ill from the flu.

Peptide discovery could advance treatment of high blood pressure

VUMC researchers found that peptides modified by highly reactive compounds called isolevuglandins activated T cells and promoted hypertension in mice. Their first-ever isolation of such peptides is a step toward potentially intervening in this pathologic process.

Study sheds new light on autism, but there’s more work to be done

A target of their investigations is serotonin, a signaling molecule that is well known for its critical roles in regulating mood and which also plays an important role in the development of the brain and nervous system.

Study reveals potential new way to stop a common kidney cancer

Vanderbilt researchers have identified cancer cell-specific genetic alterations that reprogram the immune “landscape,” thereby driving tumor growth, and discovered a potential new drug target for stopping it.

Study identifies molecule as potential target for treating AML

While immune checkpoint inhibitors that target the PD-1 molecule on T-cells have proven to be effective with many cancers, these immunotherapies have not worked for acute myeloid leukemia (AML), but new research has identified a “cousin” molecule as a potential therapeutic target for AML. 

VUMC team finds potential treatment for kidney fibrosis