monoclonal antibodies

March 4, 2021

Chikungunya antibody identified at VUMC moves forward

Evotec, a drug company headquartered in Hamburg, Germany, has begun a phase 1 clinical trial of a monoclonal antibody against the chikungunya virus that was identified at Vanderbilt University Medical Center.

By Bill Snyder
Jeff Balser, MD, PhD, talks about the many challenges VUMC has faced during the past year at this week’s Leadership assembly. (photo by Donn Jones)
February 18, 2021

Take care of you: 5 Takeaways from Leadership Assembly

In the 351 days since the COVID-19 Command Center opened to steer Vanderbilt University Medical Center through the pandemic, the workforce stepped up and contributed, keeping the health system on track to deliver care even as the landscape quaked with new challenges.

By Holly Fletcher
Ken and Kathy Hazelwood are among those who have received treatment at VUMC’s COVID Infusion Clinic.
February 10, 2021

More than 1,000 receive antibody infusions for COVID-19 at VUMC

As of Feb. 1,065 outpatients have received antibody infusions since the clinic opened on Nov. 18. Clinic officials estimated that the infusions have prevented about 70 patients from developing severe COVID-19 illness requiring hospitalization or emergency department evaluation.

By Bill Snyder
The “orange team,” led by Buddy Creech, MD, director of the Vanderbilt Vaccine Research Program, assembles in the old Clinical Research Center space in Medical Center North on the first day of the phase 3 Moderna vaccine study this summer.
December 16, 2020

Coronavirus ‘crusaders’ spur VUMC research achievements

The development of the vaccines, monoclonal antibodies and antiviral drugs that ultimately will defeat COVID-19 wouldn’t have been possible had it not been for the unflagging and selfless efforts of a global army of research nurses, laboratory personnel, recruiters and other staff.

By Bill Snyder
December 10, 2020

Exploiting viral vulnerabilities

The isolation of human monoclonal antibodies against dangerous viruses including EEEV, Hendra and Nipah could offer new ways to treat and prevent these infections.

By Bill Snyder
James Crowe Jr., MD, and colleagues are exploring how the body’s immune system gears up to fight off infection.
December 1, 2020

Vanderbilt University Medical Center’s Crowe receives 2020 “Golden Goose” Award for COVID-19 research

James Crowe Jr., MD, a physician-scientist at Vanderbilt University Medical Center who has pioneered development of human monoclonal antibodies as potential treatments for viral diseases, has won a 2020 “Golden Goose” Award.

By Bill Snyder
August 20, 2020

Study identifies antibodies that block alphaviruses

Researchers at Vanderbilt University Medical Center have identified antibodies that, in animals, block infection by alphaviruses, which can cause chronic and debilitating joint pain and arthritis and are an increasing global health concern.
By Bill Snyder
July 15, 2020

Antibody research at Vanderbilt University Medical Center shows promise in fight against COVID-19

Based on positive results in preclinical studies reported today, potently neutralizing antibodies identified by researchers at Vanderbilt University Medical Center are showing promise as a potential therapy for preventing and treating COVID-19.
By Bill Snyder
July 3, 2020

Research team isolates antibodies that may prevent rare polio-like illness in children linked to a respiratory infection

Researchers at Vanderbilt University Medical Center, Purdue University and the University of Wisconsin-Madison have isolated human monoclonal antibodies that potentially can prevent a rare but devastating polio-like illness in children linked to a respiratory viral infection.
By VUMC News and Communications
June 9, 2020

Vanderbilt, AstraZeneca collaborate on new COVID-19 antibody research

After evaluating the ability of more than 1,500 monoclonal antibodies to bind and neutralize the COVID-19 virus, SARS-CoV-2, in the laboratory, AstraZeneca signed an exclusive license to six candidate antibodies in Vanderbilt’s portfolio.
By Bill Snyder
May 14, 2020

Antibodies eye Pacific Island “fever”

Vanderbilt Vaccine Center team isolates monoclonal antibodies against Ross River virus, which causes rash, fever and debilitating muscle and joint pain lasting three to six months.
By Bill Snyder
April 30, 2020

Antibody finding raises hopes for Marburg, COVID-19 treatments

Monoclonal antibodies against Marburg virus — a more lethal cousin of the RNA virus that causes COVID-19 — may aid in the development of antibody “cocktails” to counter viral infection.
By Bill Snyder
April 8, 2020

Vanderbilt University Medical Center and AstraZeneca join forces to identify potential COVID-19 treatments

Vanderbilt University Medical Center and the global biopharmaceutical company AstraZeneca have joined forces to identify candidates for antibody-based treatments that could protect people exposed to the 2019 novel coronavirus disease, COVID-19.
By Bill Snyder