Nature Genetics (journal)

July 8, 2024

GeneMAP discovery platform will help define functions for ‘orphan’ metabolic proteins 

The combination of genomics and metabolism identified a long-sought mitochondrial choline transporter.

By Leigh MacMillan
(iStock)
May 14, 2024

Breast cancer risk variants identified for women of African ancestry

A study led by researchers from Vanderbilt-Ingram Cancer Center sheds light on some of the genetic variants that make breast cancer more deadly for women of African ancestry and significantly reduces the disparity in knowledge for assessing their genomic risk factors.

By Tom Wilemon
(iStock image)
May 1, 2024

Study finds 500 new blood pressure genes

An analysis of the genomes of more than 1 million people of European ancestry, conducted by several of the world’s leading genomic centers, including Vanderbilt University Medical Center, has identified more than 2,000 independent genetic signals for blood pressure.

By Bill Snyder
(iStock image)
April 1, 2024

Cell-specific variations in gene regulation may be key to treating pulmonary fibrosis

An international research team co-led by Vanderbilt University Medical Center has revealed how variations in gene regulation in different cell types drive pulmonary fibrosis, a progressive respiratory disorder characterized by scarring and loss of functional lung tissue.

By Bill Snyder
October 22, 2020

New tool to probe genetic mechanisms of disease

Vanderbilt Genetics Institute investigators have added a new method to the computational genetics toolbox. Their approach, described in the journal Nature Genetics, integrates vast genomics datasets to predict gene expression and facilitate discovery of genetic mechanisms underlying human diseases.

By Leigh MacMillan
December 31, 2018

Hundreds of new blood pressure gene variations discovered

By Bill Snyder
July 26, 2018

Vanderbilt study links gene expression, disease association data

An international team of researchers has integrated gene expression and disease association data to better understand the biological mechanisms of complex human diseases.
By Leigh MacMillan
June 28, 2018

Team identifies new gene candidates for breast cancer risk

Jun. 28, 2018—An international coalition led by scientists at Vanderbilt University Medical Center and the QIMR Berghofer Medical Research Institute in Herston, Australia, has identified 48 candidate susceptibility genes for breast cancer risk, including 14 genes at loci (chromosome regions) not yet reported for breast cancer.
By Bill Snyder
January 19, 2017

Metastatic pancreatic cancer ‘reprograms’ for malignancy

Metastatic pancreatic cancer — cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths — changes its metabolism and is “reprogrammed” for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics.
By Leigh MacMillan
August 21, 2014

Study in East Asians identifies genes tied to colon cancer risk

Colorectal cancer is one of the leading causes of death among populations around the world. While diet, physical activity and other lifestyle factors can influence the risk of developing the disease, hereditary factors also play an important role.
By VUMC News and Communications
July 24, 2014

Gene study focuses on breast cancer in East Asian women

A new study in East Asian women has identified three genetic changes linked to an increased risk of breast cancer. The research, led by Vanderbilt University investigators, was published online this week in Nature Genetics.
By VUMC News and Communications
April 18, 2013

BMI gene study expands to people of African ancestry

An international team of scientists, including six from Vanderbilt University, has identified the first unique genetic determinants of body mass index (BMI) in people of African ancestry.
By Bill Snyder
March 7, 2013

Eye disorder’s genetic risk factors come into focus

An international group of investigators has identified seven new genetic regions associated with age-related macular degeneration (AMD), a common cause of blindness in older individuals.
By Leigh MacMillan
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