Nucleic Acids Research (journal) Archives

Novel genetics approach enhances discovery of disease risk genes

VUMC researchers applied the new approach to large GWAS datasets for breast, prostate and lung cancers, and three brain disorders.

New findings suggest that oxidative stress damages mitochondrial DNA, and they link this damage to a disease state.

New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.

Understanding how bacteria become resistant to quinolone antibiotics could guide strategies for developing new antibacterial drugs.

Structural studies reveal a new framework for understanding a central player in DNA processing.