polygenic risk score/polygenic score

June 16, 2022

BMI genetics influence heart function

Vanderbilt researchers have discovered that a genetic predisposition to elevated body mass index increases the risk of diastolic dysfunction — a cardiac condition that can lead to heart failure.

By Leigh MacMillan
May 19, 2022

Genetics and blood pressure

Including polygenic risk scores for blood pressure may improve predictive models to identify people at risk for treatment-resistant hypertension.

By Leigh MacMillan
April 26, 2022

Calculating risk for uterine fibroids

Vanderbilt researchers have constructed a polygenic risk score for uterine fibroids that will be useful for exploring causes of these benign tumors and identifying novel drug targets and therapies.

By Leigh MacMillan
Joseph Breeyear, left, Todd Edwards, PhD, and colleagues are studying how high blood pressure genes can improve heart surgery survival in children.
March 24, 2022

High blood pressure genes improve heart surgery survival in children

Vanderbilt researchers have found that children with a genetic makeup that predicts high blood pressure as adults are more likely to survive congenital heart defect repair surgery.

By Leigh MacMillan
December 2, 2021

Study links depression scores, white blood cell count

By Emily Stembridge
June 16, 2021

VUMC joins national effort to improve disease prediction in diverse populations

Vanderbilt University Medical Center will participate in a new federal initiative aimed at improving the use of polygenic risk scores (PRS) to predict complex diseases in diverse populations.

By Bill Snyder
May 13, 2021

People at high genetic risk for colorectal cancer benefit more from lifestyle changes

People with a high polygenic risk score for colorectal cancer could benefit more at preventing the disease by leading healthy lifestyles than those at lower genetic risk, according to a study by Vanderbilt researchers published in the April issue of The American Journal of Clinical Nutrition.
By Tom Wilemon
March 11, 2021

Genotype looms large in risk for post-op arrhythmia

Postoperative atrial fibrillation (PoAF), a form of arrhythmia, complicates 20-40% of cardiac surgical procedures and 10–20% of non-cardiac thoracic operations, cropping up two to four days after surgery to pose risk of stroke, heart attack, mortality, longer hospital stays and greater cost.
By Paul Govern
March 9, 2021

Study incorporates genetics with smoking history to identify high-risk smokers for lung cancer screening

A study by Vanderbilt researchers that analyzed both smoking history and genetic risk variants for lung cancer supports modifying current guidelines to include additional smokers for lung cancer screening.
By Tom Wilemon
August 10, 2020

A step toward cancer prevention

A computational technique that combines the effect of multiple genomic variants has the potential to identify high-risk individuals for cancer prevention.
By Bill Snyder
April 23, 2020

Polygenic scores identify those at high cancer risk

A team of Vanderbilt researchers constructed polygenic risk scores (PRS) based on genomic variants associated with eight common cancers and concluded they could potentially be used for personalized risk assessments.
By Tom Wilemon
February 27, 2020

Study finds certain genetic test not useful in predicting heart disease risk

A Polygenic Risk Score — a genetic assessment that doctors have hoped could predict coronary heart disease (CHD) in patients — has been found not to be a useful predictive biomarker for disease risk.
By Matt Batcheldor
January 31, 2019

Study explores genetic risk for suicide attempt

Using data from the UK Biobank and Vanderbilt’s BioVU, a new study in the journal Molecular Psychiatry finds that approximately 4 percent of suicide attempt risk is captured by genotype data.
By Paul Govern
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