Proceedings of the National Academy of Sciences (PNAS) (journal)

Indian mother and child
February 11, 2016

Slight chemical change may improve TB treatments: study

One small chemical change to an existing antibacterial drug results in a compound that is more effective against its target enzyme in tuberculosis, Vanderbilt researchers have discovered.

By Leigh MacMillan
bacteria microbiome
February 5, 2016

Dynamics of a drug resistance transporter

Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance.

By VUMC News and Communications
January 8, 2016

Copying chromosome caps

Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports.

By Leigh MacMillan
disabled man plays with his daughter
October 29, 2015

Compound developed at VUMC may delay Huntington’s disease

A compound developed by researchers at Vanderbilt University can improve early symptoms and delay progression of Huntington’s disease in a mouse model of the neurodegenerative disorder.

By Bill Snyder
October 2, 2015

The yin and yang of COX-2

New findings add to the understanding of how the enzyme COX-2 works, which is critical to the development of COX-2-targeted anti-inflammatory drugs.

By Sanjay Mishra
August 7, 2015

Bridging the antibiotic gap

Vanderbilt researchers have discovered how certain molecules with antibiotic properties are synthesized, findings that could lead to new drugs that overcome the increased antibiotic resistance in bacteria.

By Sanjay Mishra and Bill Snyder
July 24, 2015

How to trick a wily virus

Vanderbilt investigators have discovered how human antibodies induced during testing of an experimental “bird flu” vaccine kill the virus.
By Sanjay Mishra
June 4, 2015

Study identifies C. diff toxin receptor, suggests new treatment approaches

Vanderbilt University investigators have identified a cellular receptor for a toxin from Clostridium difficile (“C. diff”) — the leading cause of hospital-acquired diarrhea in the United States.
By Leigh MacMillan
April 23, 2015

Study reveals biomarker of post-injury spinal cord function

Vanderbilt University researchers have demonstrated, for the first time in a primate model, that injury disrupts neural signaling in the spinal cord and that these changes can be measured non-invasively with functional magnetic resonance imaging (fMRI).
By Bill Snyder
April 2, 2015

Study explores driver behind lung cancer tumor progression

Vanderbilt-Ingram Cancer Center investigators have identified the mechanisms used by a gene and its binding protein to drive tumor growth in several forms of cancer, including non-small cell lung cancer.
By VUMC News and Communications
January 26, 2015

Immune response depends on force

New studies explain how T-cell receptors use force to recognize and protect us against pathogens.
By Leigh MacMillan
October 23, 2014

New view of transporter dynamics

New insights to the workings of a protein that moves neurotransmitters across the nerve cell membrane could aid the design of more effective antidepressants.
By Bill Snyder
October 16, 2014

Lymphocyte study reveals obesity clues

Vanderbilt University researchers are closer to understanding the link between obesity, chronic inflammation and type 2 diabetes.
By Bill Snyder
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