Proceedings of the National Academy of Sciences (PNAS) (journal)

New study looks at brain networks involved in free will

Using lesion network mapping, a recently developed technique for analyzing how the brain works, Ryan Darby, MD, assistant professor of Neurology at Vanderbilt, studied free will perception related to movement decisions.

Energetic gene switch

New findings link flux through glycolysis, which produces cellular energy, with transcription and gene expression via histone modification.

Predictive models for gene regulation

Using new computational approaches to understand the behavior of cells should aid efforts to predict how mutations affect cell function and how diseases respond to drug combinations.

Fueling the MATE transporter

Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.

Understanding HDL structure

Structural features of newly formed HDL particles will help guide understanding of “good cholesterol” and its function.

busy intersection

Iron-sulfur “intersection”

Vanderbilt researchers have discovered an unanticipated link between sulfur and iron balance, pointing to a genetic basis for iron-deficiency anemia.

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