Proceedings of the National Academy of Sciences (PNAS) (journal)

Cholesterol
October 2, 2014

Team spots key regulator for cholesterol production

A Vanderbilt University-led research team has discovered a “master regulator” for cholesterol production and transport in the liver — a tiny piece of RNA called microRNA-223.

By Bill Snyder
double helix
August 21, 2014

New technique accelerates genome editing process

It sounds like a potato chip. But CRISPR is actually the acronym for a new genome editing technique that, by many accounts, is accelerating the study of genes and disease.

By Bill Snyder
July 17, 2014

Regulating immune regulators

Understanding how to control the generation of regulatory T cells could have important implications for treating autoimmunity and cancer.

By Leigh MacMillan
May 23, 2014

Repair protein’s DNA recognition motif

Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

By Leigh MacMillan
March 13, 2014

A new way to target cancer-driver Ras

Vanderbilt researchers have discovered small molecules that turn off cancerous Ras signals in a new way.

By Leigh MacMillan
January 23, 2014

Human and Helicobacter co-evolution

By VUMC News and Communications
December 19, 2013

Ancient chemical bond may aid cancer therapy: study

A chemical bond discovered by Vanderbilt University scientists that is essential for animal life and which hastened the “dawn of the animal kingdom” could lead to new therapies for cancer and other diseases.
By Bill Snyder
November 8, 2013

Defusing ‘C. diff’ infection

By Leigh MacMillan
October 10, 2013

Probing mutant EGF receptor regulation

Understanding the regulation of mutant EGF receptors commonly found in lung cancers could lead to new targeted therapies.
By Leigh MacMillan
April 25, 2013

Food variety drives overeating in mouse model of obesity syndrome

Dietary variety – not high-fat or sugary foods – appears to stimulate overeating in a mouse model of an inherited obesity syndrome.
By Bill Snyder
February 21, 2013

Antibacterial protein’s molecular workings revealed

Vanderbilt investigators report new insights to the workings of calprotectin, an immune system protein that “starves” bacterial pathogens of the metal nutrients they require.
By Leigh MacMillan
January 18, 2013

Seeing light receptor’s interactions

Understanding how the main receptor for light interacts with other signaling molecules may inform new pharmaceutical development.
By Leigh MacMillan
October 23, 2012

Stomach bug alters tumor suppressor

The stomach bug Helicobacter pylori increases forms of a protein that promote tumor development, perhaps explaining how it elevates risk for gastric cancer.
By Leigh MacMillan
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