sarcoma (bone and soft tissue cancer)

July 25, 2023

Signaling pathways in liposarcomas

A broad bioinformatics approach revealed that Hedgehog signaling is upregulated in dedifferentiated liposarcoma, suggesting this pathway may be an early indicator of poor prognosis and a potential therapeutic target.

By Leigh MacMillan
From left, Xiang Ye, PhD, Suba Rajendren, PhD, Antiana Richardson, and John Karijolich, PhD, are studying how the cancer-causing virus KSHV commandeers host gene expression and regulatory machinery.
April 20, 2023

Study details RNA editing in virus-infected cancer cells

Vanderbilt researchers detail the landscape of RNA editing — a form of RNA modification — in primary effusion lymphoma cells during Kaposi’s sarcoma-associated herpesvirus infection and identify an edited viral microRNA that is critical for infection.

By Leigh MacMillan
Dominic Gamez is resuming more activities since he received an expandable prosthesis to treat osteosarcoma in his left leg.
January 12, 2023

Expandable prosthesis gives young patient more mobility

To treat the osteosarcoma in his left leg, Dominic Gamez, 7, and his family chose to have a magnetic expandable prosthesis implanted that can be manipulated to grow incrementally as the child grows.

By Nancy Humphrey
October 13, 2022

VUH adopts enhanced recovery for sarcoma surgery

Vanderbilt’s latest enhanced recovery after surgery clinical pathway was launched last month for adult patients receiving surgery to remove extremity soft tissue sarcomas, which are cancerous tumors that can arise in muscles, tendons, fat, blood vessels and other connective tissue.

By Paul Govern
September 13, 2022

Cancer registries and sarcoma research

The number of sarcoma research studies that use the two largest U.S. cancer registries is increasing, but over one-third of studies that asked the same research question reported conflicting findings.

By Leigh MacMillan
February 16, 2022

Yale surgery chair to discuss cancer’s ‘on’ switch at next Discovery Lecture

Renowned surgical oncologist and clinician scientist Nita Ahuja, MD, MBA, chair of the Department of Surgery at Yale School of Medicine, will deliver the next web-based Discovery Lecture.

By Leigh MacMillan
July 23, 2020

Cellular antiviral defenses

A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.
By Leigh MacMillan
March 28, 2019

Hot chemotherapy surgery helps save patient’s leg

Tom Deweese can keep up with his grandchildren because of a highly specialized surgery using hot chemotherapy that saved his leg.
By Tom Wilemon
October 4, 2017

Boosting sarcoma cell death

A compound identified at Vanderbilt represents a new lead for treating rare, aggressive childhood cancers called Ewing sarcomas.
By Leigh MacMillan
August 3, 2017

Children’s Hospital patient, doctor bond through music

When 17-year-old Ray Cruz was invited to perform at the Ryman Auditorium, he agreed to do it under one condition — that his doctor perform alongside him.
By VUMC News and Communications
December 10, 2015

Review highlights financial impact of sarcoma misdiagnosis

Malpractice awards and settlements are eight times greater when physicians misdiagnosis sarcoma than when they make other mistakes, according to a review of 32 years of court cases.
By Tom Wilemon
September 3, 2014

Aggressive bone cancers build more blood vessels

A subpopulation of bone cancer cells may be responsible for driving clinically aggressive behavior, suggesting new treatment options.
By Katherine Venmar
April 10, 2014

Photo: Sarcoma research support

The FTL Sarcoma Fund, in partnership with the T.J. Martell Foundation, recently presented a gift to the Vanderbilt-Ingram Cancer Center in support of sarcoma research in memory of Warner Music Nashville colleague Lindsay Walleman.
By VUMC News and Communications
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