The Lancet Respiratory Medicine (journal)

Study shows life-saving benefit of baricitinib for ventilated COVID patients

Vanderbilt research shows that critically ill COVID-19 patients on a mechanical ventilator or extracorporeal membrane oxygenation lived more often when randomized to receive baricitinib.

Rheumatoid arthritis drug combined with standard of care may help reduce mortality for hospitalized COVID-19 patients

Hospitalized patients with COVID-19 who received the rheumatoid arthritis drug baricitinib, in combination with the standard of care including corticosteroids, died less often than those receiving only the standard of care, according to a study released this week in The Lancet Respiratory Medicine.

Large study finds higher burden of acute brain dysfunction for COVID-19 ICU patients

COVID-19 patients admitted to intensive care in the early months of the pandemic were subject to a significantly higher burden of delirium and coma than is typically found in patients with acute respiratory failure. Choice of sedative medications and curbs on family visitation played a role in increasing acute brain dysfunction for these patients.

hands of elderly white woman in hospital with oxygen monitor on finger and iv in arm

Sedative-associated delirium increases risk of dementia

A Vanderbilt study of more than 1,000 intensive care unit patients around the country, nearly three-fourths of whom experienced delirium, showed that many drugs given to sedate patients in the ICU are actually increasing their chances of — and duration of — delirium instead of helping them recover.

seated man in silhouette

Physical signs of depression common among ICU survivors

Depression affects more than one out of three survivors of critical illness, according to a Vanderbilt study released in The Lancet Respiratory Medicine, and the majority of patients experience their symptoms physically rather than mentally.