Research

January 4, 2024

Potential AML therapy induces leukemic stem cell death

Vanderbilt researchers are studying a potential therapy for acute myeloid leukemia that targets the residual leukemic stem cells in bone marrow after treatment that are responsible for relapses and drug resistance.

By Tom Wilemon
January 2, 2024

Team uses COVID-19 to test automated acute disease profiling

An automated solution for creating phenotyping algorithms, PheNorm, worked well to identify symptomatic COVID-19 cases in electronic health records, suggesting that automation could speed high-throughput phenotyping of acute disease.

By Paul Govern
December 29, 2023

Glucose metabolism influences B cell function

Glucose metabolism influences the qualities of activated, mature B cells — white blood cells that are required for antibody-mediated immune responses, Vanderbilt researchers discovered.

By Leigh MacMillan
December 19, 2023

Melanoma, anyone?

Collegiate tennis and golf athletes aren’t using enough sunscreen according to a recent survey; meanwhile, the deadly skin cancer melanoma is on the rise.

By Paul Govern
Authors on the study included, from left, Jennifer Pietenpol, PhD, Melinda Sanders, MD, Brian Lehmann, PhD, Vandana Abramson, MD, and Yu Shyr, PhD. (photo by Donn Jones)
December 15, 2023

Clinical trial shows efficacy for atezolizumab combined with carboplatin

By Tom Wilemon
Ken Lau, PhD, left, and Bob Coffey, MD, have made several important discoveries about colorectal cancer that are aiding the search for new, more effective therapies. (photo by Erin O. Smith)
December 11, 2023

Colorectal cancer ‘cartography’ reveals an avenue to improved immunotherapy

Vanderbilt University Medical Center researchers have discovered why most colorectal tumors escape detection and destruction by the body’s immune system.

By Bill Snyder
December 8, 2023

Vanderbilt research presented at Cancer Moonshot meet

Vanderbilt Colorectal cancer expert Bob Coffey, MD, was recently invited to present his research to representatives of President Joe Biden’s reignited Cancer Moonshot initiative.
By Bill Snyder
December 8, 2023

Gut microbiota metabolite protects against obesity: study

Vanderbilt researchers have discovered that beneficial bacteria in the small intestines produce a compound that protects against obesity.
By Leigh MacMillan
December 8, 2023

You missed a few: a better way to count health care-associated influenza cases

The traditional definition of health care-associated influenza leads to gross undercounting, a Vanderbilt study suggests.
By Paul Govern
December 7, 2023

How to get the biggest “bang” for the research “buck”

Vanderbilt researchers are developing new methods to maximize what can be learned from clinical trials and cohort studies, while maintaining their rigor and reproducibility.
By Bill Snyder
December 6, 2023

Pasteurization reduces bioactive component of breast milk

Pasteurization of breast milk affects the concentration of osteopontin, a bioactive protein with roles in intestinal, immunological and brain development — suggesting that osteopontin supplementation should be considered when donor milk is provided to preterm infants.
By Leigh MacMillan
December 5, 2023

Role of immunity in kidney injury hints at a potential therapy: study

Targeting the cytokine IL-22 could be a new therapeutic approach to prevent kidney injury caused by drugs or toxins, Vanderbilt researchers have discovered.
By Bill Snyder
December 4, 2023

Study links gene network and pancreatic beta cell defects to Type 2 diabetes

A comprehensive study that integrates multiple analytic approaches has linked a regulatory gene network and functional defects in insulin-producing pancreatic beta cells to Type 2 diabetes.
By Leigh MacMillan and Jill Clendening
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