Research

July 1, 2021

Preclinical study supports rigosertib as booster to immunotherapy treatment for melanoma

A team of Vanderbilt researchers have shown in a preclinical study that the investigational drug rigosertib could be a potential booster treatment to elicit response to immunotherapies among melanoma patients.

By Tom Wilemon
June 22, 2021

Treating metastatic prostate cancer

An indirect comparative effectiveness study using published data suggests that the targeted therapy olaparib should be re-evaluated for treating metastatic prostate cancer.

By Leigh MacMillan
June 22, 2021

Combination antibody therapies should retain effectiveness against emerging COVID-19 variants: study

Five monoclonal antibody “cocktails,” including one developed at Vanderbilt University Medical Center (VUMC), are protective in animal studies against several variant strains of COVID-19, according to a report this week in the journal Nature.

By Bill Snyder
June 21, 2021

Dexmedetomidine and delirium

The sedative dexmedetomidine, when administered during or after heart surgery, is associated with postoperative delirium and adverse outcomes.

By Paul Govern
June 17, 2021

COVID-19 complication underdiagnosed

A mysterious inflammatory syndrome linked to COVID-19 infection and first identified in children also occurs in adults, Vanderbilt researchers report.

By VUMC News and Communications
June 17, 2021

Drug allergy labels in medical records power searches for gene-drug associations

By Paul Govern
June 17, 2021

New neurodegeneration culprit

A young woman with a puzzling neurological illness and novel genetic variant pointed investigators to a role for dysregulated protein kinase D1 in neurodegeneration.
By Paul Govern
June 8, 2021

VUMC team develops potential treatment for life-threatening microbial inflammation

A cell-penetrating peptide developed by researchers at Vanderbilt University Medical Center can prevent, in an animal model, the often-fatal septic shock that can result from bacterial and viral infections.
By Bill Snyder
June 3, 2021

‘Secret shopper’ study sheds light on barriers to opioid treatment for women

After a 2020 Vanderbilt University Medical Center study showed women have a difficult time accessing treatment for opioid use disorder (OUD), investigators analyzed comments received from the study’s participants to further shed light on barriers to care, which included everything from long on-hold times to difficult interactions with clinic receptionists during phone calls seeking appointments.
By Jill Clendening
June 3, 2021

VUMC team discovers new genetic disease

Researchers at Vanderbilt University Medical Center have discovered a new genetic disease that causes a severe form of neurogenic orthostatic hypotension, a rapid drop in blood pressure upon standing that can cause fainting.
By Bill Snyder
June 3, 2021

Predictive model identifies patients for genetic testing

Patients who, perhaps unbeknownst to their health care providers, are in need of genetic testing for rare undiagnosed diseases can be identified en masse based on routine information in electronic health records (EHRs), a research team reported June 3 in the journal Nature Medicine.
By Paul Govern
May 26, 2021

Vanderbilt researchers present new data on clinical trials at ASCO 2021

Vanderbilt-Ingram Cancer Center researchers will present data on clinical trials involving targeted therapies, immunotherapies and drug combination synergies at the 2021 American Society of Clinical Oncology Annual Meeting, June 4-8. The meeting is a virtual event this year.
By Tom Wilemon
May 25, 2021

Heat for hypertension in autonomic failure

Heat therapy could offer a novel nonpharmacologic approach for treating the overnight hypertension that affects patients with autonomic failure.
By Leigh MacMillan