Department of Biochemistry

The team studying tumor suppressor protein p53 includes, from left, Jennifer Pietenpol, PhD, and Lindsay Redman-Rivera.
September 2, 2021

Discovery offers insight for development of cancer therapies targeting mutant p53

Vanderbilt researchers have discovered that aneuploidy (an abnormal number of chromosomes) drives malignant phenotypes in cells expressing mutant p53, a tumor suppressor protein that is mutated in more than half of all human cancers.

By Bill Snyder
August 19, 2021

Expression atlas for cell regulators

Vanderbilt researchers report a comprehensive tissue-specific atlas of protein and mRNA expression for p63 and p73, members of the p53 family signaling network that is the most frequent target of mutations in human cancers.

By Leigh MacMillan
July 29, 2021

Cortez named chair of Department of Biochemistry

David Cortez, PhD, Richard N. Armstrong, PhD, Professor of Innovation in Biochemistry and professor of Biochemistry, has been appointed chair of the Department of Biochemistry.

By Wendy Bindeman
Madison Adolph, PhD, left, David Cortez, PhD, and Archana Krishnamoorthy are studying fundamental processes involved in DNA replication.
July 22, 2021

Researchers discover that protein switches functions to regulate DNA replication

Vanderbilt biochemists have discovered what the DNA damage response protein RADX does — and how it does it.

By Leigh MacMillan
July 22, 2021

Osheroff elected to AAMC council leadership post

Neil Osheroff, PhD, professor of Biochemistry and Medicine, has been elected to a leadership position for a council of the Association of American Medical Colleges (AAMC).

By Leigh MacMillan
July 15, 2021

Susan G. Komen funds VICC breast cancer initiatives

Susan G. Komen has announced breast cancer research grants totaling $14 million, including funding for three separate initiatives led by Vanderbilt-Ingram Cancer Center (VICC) researchers.

By Tom Wilemon
April 15, 2021

Arrhythmia culprit: supertrafficking ion channel

Charles Sanders, PhD, and colleagues show how a “supertrafficking” mutant potassium channel contributes to heart rhythm abnormalities.
By Leigh MacMillan
April 8, 2021

VICC researchers featured at AACR Annual Meeting

Researchers from Vanderbilt-Ingram Cancer Center will have a robust presence during the first session of the American Association for Cancer Research (AACR) Annual Meeting, April 10-15, as presenters, panelists and authors.
By Tom Wilemon
February 4, 2021

Gene network for leukemia factor

A new method speeds the analysis of factors that control gene expression from days to minutes, allowing researchers to uncover new targets for cancer treatment.
By Leigh MacMillan
December 8, 2020

Cortez named interim chair of the Department of Biochemistry; York named Impossible Foods chief science officer

David Cortez, PhD, Richard N. Armstrong Professor of Innovation in Biochemistry and professor of biochemistry, has been named interim chair in the Department of Biochemistry beginning Jan. 1, 2021.
By Marissa Shapiro 
July 23, 2020

Cellular antiviral defenses

A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.
By Leigh MacMillan
June 18, 2020

Probing DNA damage repair

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works.
By Leigh MacMillan
June 18, 2020

Cortez named to VICC research leadership role

David Cortez, PhD, has been named associate director for Basic Science Research at Vanderbilt-Ingram Cancer Center (VICC).
By Tom Wilemon
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