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COVID-19 complication underdiagnosed

Jun. 17, 2021, 10:30 AM

by Shivani Sharma

Multisystem inflammatory syndrome (MIS) is the inflammation of various tissues and has been cited as a complication of SARS-CoV-2 infection. Originally identified in children, a form of MIS has since been described in adults (MIS-A).  

Giovanni Davogustto, MD, and colleagues identified and collected characteristics of adult patients at risk of MIS-A from electronic health records to better understand its presentation. Patients in the study were narrowed from the pool of patients testing positive for SARS-CoV-2 and separated from those experiencing acute COVID-19 infection.   

The research published in JAMA Network Open showed that the average patient affected by MIS-A was younger than the average patient admitted for acute COVID-19 symptoms. Four organ systems were typically involved, with the most common being the gastrointestinal tract, kidneys and hematologic system.  

These data suggest a larger variation in clinical presentation, lower illness severity, and underdiagnosis of MIS-A than previously thought. With further research, more MIS-A cases can be properly identified and treated. 

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