JAMA Network Open (journal) Archive — Page 1 of 5

July 24, 2026

Study shows one-fifth of prescribed cancer drugs initially denied coverage in Medicare were overturned when reviewed

The most common reason for initial denials was “non-medically acceptable” indications, or drugs prescribed “off-label,” which means using a drug outside its formally approved indication.

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May 18, 2026

Study finds benefit in genotype-guided care for depression

Genetic variants known to slow or speed metabolism of drugs for depression and anxiety disorders are very common.

March 10, 2026

Loneliness is a critical step on the road to suicide: Study

Mental health treatment is often out of reach. A person-centered approach to reducing loneliness that helps people engage with others might be more feasible.

February 27, 2026

Demographic and histologic factors influence risk of colon polyp recurrence

Vanderbilt Health study supports shift toward dynamic surveillance that extends monitoring for patients with specific demographic and histologic risk profiles.

February 25, 2026

Prevalence of US youth who are overweight or with obesity raises concerns: Study

Childhood obesity, which starts early, contributes to health issues throughout life.

February 11, 2026

Vaccination cuts risk of COVID-19 respiratory failure or death by 80%

Researchers at Vanderbilt Health and around the country continue to evaluate the effectiveness of vaccines approved by the Food and Drug Administration to reduce the severity and lethality of respiratory infections caused by the ever-mutating SARS-CoV-2 virus.