Leigh MacMillan

Bone matrix changes during aging

Changes to the bone matrix that occur during aging may point to novel targets for treating osteoporosis.

Structural views of a C. diff toxin

D. Borden Lacy and colleagues used cryo-electron microscopy to define the structure of a C. diff toxin, providing a framework for the design of novel therapeutics.

Chris Pua’s behind-the-scenes work brings him into spotlight

He hopes the software applications and systems he and his team develop work so well that users don’t even notice them.

Cell fate signaling

A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy.

Protein dynamics in the beating heart

To study the dynamics of structural proteins in the heart, Vanderbilt investigators generated a cellular tool they expect will be useful for screening drugs that affect heart muscle contraction.

A new anti-seizure target?

Vanderbilt neurologists have identified a protein modification that could be targeted to reduce neuronal excitability in epilepsy.

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