cancer

Vanderbilt researchers have discovered that activation of a certain signaling pathway protects brain cancers from targeted therapies, suggesting that using therapeutics that block both pathways may be a promising treatment.

A newly discovered mechanism that helps cancer cells avoid destruction by immune system cells may improve immunotherapies.

A genetic mutation that promotes cancer development blocks the normal sorting of a protein called “Argonaute 2.”

Signaling by a receptor that is overexpressed in aggressive forms of breast cancer has been linked to glutamine metabolism, suggesting new anti-cancer therapeutic targets.

The rigidity of the microenvironment around cancer cells drives invasive behavior through distinct ROCK signaling pathways, which could guide the development of specific anti-invasive therapies.

Actin and microtubule cytoskeletons are coordinated during cytokinesis – the process that separates one cell into two and is linked to events underlying cancer.

Aron Parekh, Ph.D., assistant professor of Otolaryngology, has received a four-year, $790,000 Research Scholar Grant from the American Cancer Society to further his research into the mechanical and biological properties of cancer cells and the methods by which they leave the initial tumor and spread or metastasize to other parts of the body.