inflammation

November 29, 2018

Parsing diabetic skin infections

Vanderbilt researchers have discovered a role for an inflammatory mediator in diabetic skin infections, suggesting new therapeutic targets for this common complication of diabetes.

By Paul Govern
November 1, 2018

Team’s findings show glutamine metabolism affects T cell signaling

The cellular nutrient glutamine launches a metabolic signaling pathway that promotes the function of some immune system T cells and suppresses others, Vanderbilt researchers have discovered.

By Leigh MacMillan
October 12, 2018

Asthma’s androgen connection

New findings may explain why the prevalence of asthma is higher in women and suggest that testosterone derivatives may be useful for treating more severe types of asthma.

By VUMC News and Communications
July 2, 2018

SMAD4 clue to colon cancer

Loss of a gene that is part of the TGF-beta signaling pathway increased inflammation in the colon and was observed in half of human colitis-associated cancers.

By Bill Snyder
3d rendering white blood cells with red blood cells
May 9, 2018

Putting the brakes on sepsis

An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.

By Leigh MacMillan
January 16, 2018

A spicy finding

Vanderbilt researchers have discovered that curcumin — the active ingredient in the spice turmeric — needs to be metabolically activated to exert anti-inflammatory effects.

By Leigh MacMillan
January 4, 2018

Asthma study may point to potential new therapeutic approach

New findings from Vanderbilt suggest that blocking the migration of cells involved in asthma may represent a new approach for treating the respiratory condition.
By Leigh MacMillan
November 13, 2017

Salt, inflammation and hypertension

Vanderbilt researchers have identified a pathway that links excess sodium, inflammation and hypertension.
By Leigh MacMillan
November 1, 2017

Bioactive lipids and rheumatoid arthritis

An enzyme that produces bioactive fatty acids has elevated activity in patients with rheumatoid arthritis, supporting further studies to understand its biologic roles in the disease.
By Leigh MacMillan
October 12, 2017

A switch for autoimmunity

Vanderbilt investigators have discovered a class of compounds that inhibit a mediator of inflammation and autoimmune disorders, and that could pave the way for development of future therapies.
By VUMC News and Communications
June 9, 2017

Flip side of gut protection

Vanderbilt investigators report that dysregulation of certain immune cells in the intestines may lead to inflammation and disease.
By Laura Daniel
November 3, 2016

A DARPP role in gastric cancer

Vanderbilt researchers have discovered a link between Helicobacter pylori infection, inflammation and gastric cancer that could suggest new anti-cancer therapies.
By Sanjay Mishra
September 8, 2016

Going after the ‘heart attack gremlin’

A protein called Gremlin 2 controls the extent of inflammation after heart attack and may be a good therapeutic target.
By Sanjay Mishra
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